Cognitive
Dihexa
Also known as: N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide · PNB-0408
Cognitive & Sleep In stock Box of 10 vials 1 reference
Orally-active angiotensin IV analogue studied as a procognitive HGF/c-Met potentiator.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| DI10 | 10 mg | 10 vials / box |
Order Dihexa
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Dihexa is a metabolically stabilised, blood–brain-barrier-permeant analogue of angiotensin IV developed at Washington State University. Its proposed mechanism is potentiation of hepatocyte growth factor (HGF) signalling through the c-Met receptor, driving synaptogenesis.
In the defining study, Dihexa and related analogues reversed scopolamine-induced spatial-memory deficits in rats and improved performance in aged animals, with oral activity and a long duration of effect 1.
At a glance
- Angiotensin IV analogue; HGF/c-Met potentiator
- Procognitive in scopolamine and aged-rat models
- 10 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Formula
- C27H44N4O4
- Mol. weight
- 488.7 g/mol
- CAS No.
- 1401708-83-5
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- McCoy AT, Benoist CC, Wright JW, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2012;344(1):141-54.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.
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