Cognitive
PE-22-28
Also known as: Spadin analogue · TREK-1 inhibitor
Cognitive & Sleep In stock Box of 10 vials 1 reference
Shortened spadin analogue — a TREK-1 channel inhibitor with rapid antidepressant-like activity.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| PE10 | 10 mg | 10 vials / box |
Order PE-22-28
Pricing is quoted directly and is competitive at every tier — message us with the SKUs you want and quantities for a quote.
Replies within 36 hours. Cryptocurrency (preferred) or card / money-app with a processing fee. COA for this batch available on request.
PE-22-28 is a seven-residue analogue of spadin, a natural peptide derived from sortilin propeptide that blocks the TREK-1 background potassium channel. TREK-1 inhibition is a validated antidepressant mechanism in rodent models.
Shortened spadin analogues including PE-22-28 displayed stronger TREK-1 inhibition, greater in-vivo stability and faster antidepressant-like activity than the parent peptide, with effects evident after four days of treatment 1.
At a glance
- TREK-1 potassium-channel inhibitor
- Rapid antidepressant-like effect in rodent models
- 10 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Sequence
- Gly-Val-Ser-Trp-Gly-Leu-Arg
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- Djillani A, Pietri M, Moreno S, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition,Stability and Antidepressant Activity. Front Pharmacol. 2017;8:643.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.
Related