Recovery
TB-500
Also known as: Thymosin β4 acetate · Thymosin beta-4 fragment · Tβ4
Recovery & Repair In stock Box of 10 vials 3 references
Thymosin β4-derived peptide studied in wound repair, cell migration and inflammation resolution.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| BT5 | 5 mg | 10 vials / box | |
| BT10 | 10 mg | 10 vials / box |
Order TB-500
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TB-500 is the research designation for synthetic thymosin β4 (or its active fragment, supplied here as the acetate salt). Thymosin β4 is a 43-residue actin-sequestering protein present in almost all cells; its actin-binding motif (LKKTETQ, residues 17–23) is responsible for promoting cell migration and wound repair 2.
Reviews of the basic and clinical literature describe thymosin β4 accelerating dermal, corneal and cardiac repair in animal models and in early clinical trials 1. More recent work shows it limits inflammation by promoting autophagy 3.
At a glance
- Actin-binding, pro-migratory repair peptide
- Clinical-stage in dermal and ophthalmic wound healing
- 5 mg and 10 mg vials; also blended with BPC-157
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Formula
- C212H350N56O78S
- Mol. weight
- 4963.4 g/mol
- CAS No.
- 77591-33-4
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- Goldstein AL, Kleinman HK Advances in the basic and clinical applications of thymosin β4. Expert Opin Biol Ther. 2015;15 Suppl 1:S139-45.
- Sosne G, Qiu P, Goldstein AL, et al. Biological activities of thymosin beta4 defined by active sites in short peptide sequences. FASEB J. 2010;24(7):2144-51.
- Renga G, Oikonomou V, Stincardini C, et al. Thymosin β4 limits inflammation through autophagy. Expert Opin Biol Ther. 2018;18(sup1):171-175.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.
Related
Often ordered together
Recovery Blend
BPC-157 + TB-500
BPC/TB blend · Recovery blend
The two most-studied repair peptides co-formulated 1:1.
10 mg (5 + 5)20 mg (10 + 10)
Skin