SS-31 2 sizes RESEARCH USE ONLY BLACK BOX BIOTECHNOLOGY · 2S10

SS-31

Also known as: Elamipretide · Bendavia · MTP-131 · D-Arg-Dmt-Lys-Phe-NH2
Longevity & Mitochondrial In stock Box of 10 vials 3 references

Mitochondria-targeted tetrapeptide that binds cardiolipin and restores bioenergetics.

Available sizes

SKUPer vialPack
2S10 10 mg 10 vials / box
2S50 50 mg 10 vials / box

Order SS-31

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SS-31 (elamipretide) is a synthetic aromatic-cationic tetrapeptide that concentrates >1000-fold in the inner mitochondrial membrane, where it binds selectively to cardiolipin. This interaction stabilises cristae structure, optimises electron-transport-chain efficiency and reduces reactive-oxygen generation.

SS-31 is described as the first-in-class cardiolipin-protective compound, restoring mitochondrial bioenergetics in aged and diseased tissues across cardiac, renal, neural and skeletal-muscle models 123. It has progressed to late-stage clinical trials in mitochondrial disease.

At a glance

  • Cardiolipin-binding, cristae-stabilising peptide
  • Clinical-stage (elamipretide) in Barth syndrome and mitochondrial myopathy
  • 10 mg and 50 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
Form
Lyophilized powder
Purity
HPLC-verified — Certificate of Analysis available on request
Pack size
Box of 10 vials
Storage
Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
Sequence
D-Arg-2',6'-Dmt-Lys-Phe-NH2
Formula
C32H49N9O5
Mol. weight
639.8 g/mol
CAS No.
736992-21-5

Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.

  1. Szeto HH First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol. 2014;171(8):2029-50.
  2. Szeto HH, Birk AV Serendipity and the discovery of novel compounds that restore mitochondrial plasticity. Clin Pharmacol Ther. 2014;96(6):672-83.
  3. Szeto HH Stealth Peptides Target Cellular Powerhouses to Fight Rare and Common Age-Related Diseases. Protein Pept Lett. 2018;25(12):1108-1123.

Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.

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