Longevity
MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA type-c · Mitochondrial-derived peptide
Longevity & Mitochondrial In stock Box of 10 vials 1 reference
Mitochondrial-encoded 16-residue peptide that regulates metabolic homeostasis via AMPK.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| MS5 | 5 mg | 10 vials / box | |
| MS10 | 10 mg | 10 vials / box | |
| MS20 | 20 mg | 10 vials / box | |
| MS40 | 40 mg | 10 vials / box |
Order MOTS-c
Pricing is quoted directly and is competitive at every tier — message us with the SKUs you want and quantities for a quote.
Replies within 36 hours. Cryptocurrency (preferred) or card / money-app with a processing fee. COA for this batch available on request.
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — one of the 'mitochondrial-derived peptides' that act as retrograde signals from mitochondria to the nucleus. It targets the folate–methionine cycle, raising AICAR and activating AMPK in skeletal muscle.
In the defining study, MOTS-c administration in mice prevented diet-induced obesity and age-dependent insulin resistance, enhancing glucose utilisation and metabolic flexibility 1.
At a glance
- Mitochondrial-derived peptide; AMPK activator
- Prevents diet-induced obesity and insulin resistance in mice
- 5, 10, 20 and 40 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Formula
- C101H152N28O22S2
- Mol. weight
- 2174.6 g/mol
- CAS No.
- 1627580-64-6
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-54.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.
Related