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Selank 3 sizes RESEARCH USE ONLY BLACK BOX BIOTECHNOLOGY · SK5

Selank

Also known as: TP-7 · Thr-Lys-Pro-Arg-Pro-Gly-Pro · Tuftsin analogue
Cognitive & Sleep In stock Box of 10 vials 3 references

Tuftsin-derived heptapeptide with anxiolytic and nootropic activity in preclinical models.

Available sizes

SKUPer vialPack
SK5 5 mg 10 vials / box
SK10 10 mg 10 vials / box
SK30 30 mg 10 vials / box

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Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) built from the immunomodulatory tetrapeptide tuftsin plus the stabilising Pro-Gly-Pro tail. Developed alongside Semax in Moscow, it is characterised as an anxiolytic with nootropic properties and no sedative or muscle-relaxant effects.

In mice, Selank attenuated apomorphine-induced dopaminergic hyperactivity comparably to olanzapine; the effect was naloxone-blocked, implicating modulation of the endogenous opioid system 2. Further rodent work shows Selank protects against ethanol-induced memory impairment 1 and attenuates aversive signs of morphine withdrawal 3.

At a glance

  • Anxiolytic/nootropic tuftsin analogue
  • Modulates enkephalin degradation and GABAergic signalling
  • 5, 10 and 30 mg vials; also blended with Semax
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
Form
Lyophilized powder
Purity
HPLC-verified — Certificate of Analysis available on request
Pack size
Box of 10 vials
Storage
Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Formula
C33H57N11O9
Mol. weight
751.9 g/mol
CAS No.
129954-34-3

Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.

  1. Kolik LG, Nadorova AV, Antipova TA, et al. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bull Exp Biol Med. 2019;167(5):641-644.
    doi:10.1007/s10517-019-04588-9 PubMed 31625062
  2. Meshavkin VK, Kost NV, Sokolov OY, et al. Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system. Bull Exp Biol Med. 2006;142(5):598-600.
    doi:10.1007/s10517-006-0428-1 PubMed 17415472
  3. Konstantinopolsky MA, Chernyakova IV, Kolik LG Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bull Exp Biol Med. 2022;173(6):730-733.
    doi:10.1007/s10517-022-05624-x PubMed 36322304

Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.

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