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IGF-1 LR3 2 sizes RESEARCH USE ONLY BLACK BOX BIOTECHNOLOGY · IG01

IGF-1 LR3

Also known as: Long R3 IGF-1 · Long-[Arg3]-IGF-I
Growth Hormone Axis In stock Box of 10 vials 3 references

83-residue IGF-1 analogue with reduced binding-protein affinity and extended activity.

Available sizes

SKUPer vialPack
IG01 0.1 mg 10 vials / box
IG1 1 mg 10 vials / box

Order IGF-1 LR3

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IGF-1 LR3 is a recombinant analogue of insulin-like growth factor 1 with an Arg substitution at position 3 and a 13-residue N-terminal extension. These changes dramatically reduce affinity for IGF-binding proteins, increasing free, biologically active concentration 1.

In rat studies, IGF-1 variants with reduced binding-protein affinity were more anabolic than native IGF-1 — increasing body weight and nitrogen retention at lower doses 2. Structural characterisation by NMR confirmed the analogue retains the native IGF-1 fold 3.

At a glance

  • Reduced IGFBP binding → higher free activity
  • Anabolic potency exceeds native IGF-1 in rodent models
  • 0.1 mg and 1 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
Form
Lyophilized powder
Purity
HPLC-verified — Certificate of Analysis available on request
Pack size
Box of 10 vials
Storage
Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
Formula
C400H625N111O115S9
Mol. weight
9111 g/mol
CAS No.
946870-92-4

Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.

  1. Francis GL, Ross M, Ballard FJ, et al. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. J Mol Endocrinol. 1992;8(3):213-23.
    doi:10.1677/jme.0.0080213 PubMed 1378742
  2. Tomas FM, Knowles SE, Owens PC, et al. Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. Biochem J. 1992;282 ( Pt 1)(Pt 1):91-7.
    doi:10.1042/bj2820091 PubMed 1371669
  3. Laajoki LG, Le Breton E, Shooter GK, et al. Secondary structure determination of 15N-labelled human Long-[Arg-3]-insulin-like growth factor 1 by multidimensional NMR spectroscopy. FEBS Lett. 1997;420(1):97-102.
    doi:10.1016/s0014-5793(97)01496-8 PubMed 9450557

Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.

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