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HGH Fragment 176-191 6 sizes RESEARCH USE ONLY BLACK BOX BIOTECHNOLOGY · FR1

HGH Fragment 176-191

Also known as: Growth hormone fragment 176-191 · hGH 176-191
Metabolic & GLP-1 In stock Box of 10 vials 3 references

The lipolytic C-terminal fragment of human growth hormone.

Available sizes

SKUPer vialPack
FR1 1 mg 10 vials / box
FR2 2 mg 10 vials / box
FR5 5 mg 10 vials / box
FR10 10 mg 10 vials / box
FR12 12 mg 10 vials / box
RF15 15 mg 10 vials / box

Order HGH Fragment 176-191

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HGH Fragment 176-191 is the 16-residue C-terminal segment of human growth hormone, the region identified as responsible for hGH's lipolytic activity. It is the parent sequence of the stabilised analogue AOD-9604.

Molecular and cellular studies of this domain showed that it stimulates lipolysis and inhibits lipogenesis in adipocytes through mechanisms independent of the GH receptor and without the insulin-antagonising effects of full-length hGH 12. Chronic administration in obese mice reduced body-weight gain and increased fat oxidation 3.

At a glance

  • Native lipolytic domain of hGH (residues 176–191)
  • Six vial sizes from 1 mg to 15 mg
  • Parent sequence of AOD-9604
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
Form
Lyophilized powder
Purity
HPLC-verified — Certificate of Analysis available on request
Pack size
Box of 10 vials
Storage
Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
Sequence
Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Formula
C78H125N23O23S2
Mol. weight
1817.1 g/mol
CAS No.
66004-57-7

Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.

  1. Ng FM, Jiang WJ, Gianello R, et al. Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats. J Mol Endocrinol. 2000;25(3):287-98.
    doi:10.1677/jme.0.0250287 PubMed 11116208
  2. Ng FM, Sun J, Sharma L, et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8.
    doi:10.1159/000053183 PubMed 11146367
  3. Heffernan M, Summers RJ, Thorburn A, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001;142(12):5182-9.
    doi:10.1210/endo.142.12.8522 PubMed 11713213

Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.

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