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CJC-1295 (No DAC) 3 sizes RESEARCH USE ONLY BLACK BOX BIOTECHNOLOGY · CND2

CJC-1295 (No DAC)

Also known as: Modified GRF (1-29) · Mod GRF 1-29 · tetrasubstituted GHRH (1-29)
Growth Hormone Axis In stock Box of 10 vials 2 references

Tetra-substituted GHRH(1-29) analogue for pulsatile GH-release research.

Available sizes

SKUPer vialPack
CND2 2 mg 10 vials / box
CND5 5 mg 10 vials / box
CND10 10 mg 10 vials / box

Order CJC-1295 (No DAC)

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CJC-1295 without DAC — more precisely Modified GRF (1-29) — is the 29-residue active fragment of GHRH with four amino-acid substitutions (D-Ala2, Gln8, Ala15, Leu27) that resist enzymatic degradation and improve receptor binding. Without the Drug Affinity Complex it retains a short half-life, producing pulsatile GH release that mirrors endogenous physiology 2.

The tetra-substituted sequence is the peptide backbone of the DAC-conjugated CJC-1295 characterised by Teichman and colleagues, which produced sustained, dose-dependent elevations of GH and IGF-1 in healthy adults 1.

At a glance

  • GHRH(1-29) with four stabilising substitutions
  • Short half-life — pulsatile GH-release model
  • 2, 5 and 10 mg vials; also blended with ipamorelin
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
Form
Lyophilized powder
Purity
HPLC-verified — Certificate of Analysis available on request
Pack size
Box of 10 vials
Storage
Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
Sequence
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Formula
C152H252N44O42
Mol. weight
3367.9 g/mol
CAS No.
863288-34-0

Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.

  1. Teichman SL, Neale A, Lawrence B, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2005;91(3):799-805.
    doi:10.1210/jc.2005-1536 PubMed 16352683
  2. Grossman A, Savage MO, Besser GM Growth hormone releasing hormone. Clin Endocrinol Metab. 1986;15(3):607-27.
    doi:10.1016/s0300-595x(86)80012-3 PubMed 2429796

Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.

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