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AOD-9604 2 sizes RESEARCH USE ONLY BLACK BOX BIOTECHNOLOGY · 5AD

AOD-9604

Also known as: hGH fragment 177-191 · Anti-obesity drug 9604
Metabolic & GLP-1 In stock Box of 10 vials 3 references

Modified C-terminal fragment of human growth hormone studied for lipolytic activity without IGF-1 effects.

Available sizes

SKUPer vialPack
5AD 5 mg 10 vials / box
10AD 10 mg 10 vials / box

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AOD-9604 is a synthetic analogue of the C-terminal region of human growth hormone (residues 177–191) with a tyrosine added at the N-terminus. It was developed to isolate the lipolytic domain of hGH from its growth-promoting and insulin-antagonising actions.

In obese mice, chronic AOD-9604 administration increased fat oxidation and reduced body weight without affecting food intake or inducing insulin resistance 12. Metabolic studies in ob/ob mice reported increased lipolysis and reduced lipogenesis in adipose tissue 3.

At a glance

  • Lipolytic hGH domain, no IGF-1 elevation reported in rodent studies
  • Studied in ob/ob and diet-induced obesity models
  • 5 mg and 10 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
Form
Lyophilized powder
Purity
HPLC-verified — Certificate of Analysis available on request
Pack size
Box of 10 vials
Storage
Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
Sequence
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide)
Formula
C78H123N23O23S2
Mol. weight
1815.1 g/mol
CAS No.
221231-10-3

Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.

  1. Heffernan MA, Thorburn AW, Fam B, et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001;25(10):1442-9.
    doi:10.1038/sj.ijo.0801740 PubMed 11673763
  2. Heffernan M, Summers RJ, Thorburn A, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001;142(12):5182-9.
    doi:10.1210/endo.142.12.8522 PubMed 11713213
  3. Ng FM, Sun J, Sharma L, et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8.
    doi:10.1159/000053183 PubMed 11146367

Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.

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