Longevity
5-Amino-1MQ
Also known as: 5-amino-1-methylquinolinium · NNMT inhibitor
Metabolic & GLP-1 In stock Box of 10 vials 1 reference
Small-molecule NNMT inhibitor studied in adipocyte and diet-induced obesity models.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| 5AM | 5 mg | 10 vials / box | |
| 10AM | 10 mg | 10 vials / box | |
| 50AM | 50 mg | 10 vials / box |
Order 5-Amino-1MQ
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5-Amino-1MQ is a membrane-permeable small molecule (not a peptide) that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme upregulated in adipose tissue during obesity that consumes NAD+ precursors and S-adenosylmethionine.
In the original characterisation, 5-amino-1MQ inhibited NNMT with high selectivity, reduced intracellular 1-methylnicotinamide in adipocytes, and — in diet-induced obese mice — reduced body-weight gain, adipose mass and adipocyte size while improving cholesterol levels 1.
At a glance
- Selective, cell-permeable NNMT inhibitor
- Small molecule — supplied lyophilized like our peptides
- 5, 10 and 50 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Formula
- C10H11N2+
- Mol. weight
- 159.2 g/mol (cation)
- CAS No.
- 42464-96-0
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- Neelakantan H, Vance V, Wetzel MD, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2017;147:141-152.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.
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