Recovery
KPV
Also known as: Lys-Pro-Val · α-MSH (11-13) · Lysine-Proline-Valine
Recovery & Repair In stock Box of 10 vials 2 references
The C-terminal tripeptide of α-MSH, studied for anti-inflammatory activity in the gut.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| KPV5 | 5 mg | 10 vials / box | |
| KPV10 | 10 mg | 10 vials / box | |
| KPV30 | 30 mg | 10 vials / box |
Order KPV
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KPV is the three C-terminal residues of α-melanocyte-stimulating hormone (α-MSH). It retains the anti-inflammatory activity of the parent hormone without its pigmentary effects, and is small enough to be transported into cells by the peptide transporter PepT1.
In murine colitis models, KPV taken up via PepT1 reduced intestinal inflammation, inhibiting NF-κB activation and pro-inflammatory cytokine secretion in intestinal epithelial and immune cells 1. Colon-targeted nanoparticle delivery of KPV reduced inflammation at doses 12,000-fold lower than free peptide 2.
At a glance
- Anti-inflammatory α-MSH fragment, PepT1-transported
- Published in Gastroenterology (colitis models)
- 5, 10 and 30 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Sequence
- Lys-Pro-Val
- Formula
- C16H30N4O4
- Mol. weight
- 342.4 g/mol
- CAS No.
- 67727-97-3
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2007;134(1):166-78.
- Laroui H, Dalmasso G, Nguyen HT, et al. Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model. Gastroenterology. 2009;138(3):843-53.e1-2.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.
Related
Often ordered together
Skin Blend
GHK-Cu + KPV
Copper peptide + KPV blend
Copper tripeptide with the anti-inflammatory α-MSH tripeptide.
110 mg (100 + 10)
Recovery Blend
KLOW Blend
GHK-Cu + TB-500 + BPC-157 + KPV · Four-peptide repair blend
Four-peptide repair and anti-inflammatory co-formulation.
80 mg (50 + 10 + 10 + 10)
Recovery