Longevity
FOXO4-DRI
Also known as: FOX4 · FOXO4 D-retro-inverso peptide · Proxofim
Longevity & Mitochondrial In stock Box of 10 vials 1 reference
Senolytic peptide that disrupts the FOXO4–p53 interaction to trigger apoptosis of senescent cells.
Available sizes
| SKU | Per vial | Pack | |
|---|---|---|---|
| F410 | 10 mg | 10 vials / box |
Order FOXO4-DRI
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FOXO4-DRI is a D-retro-inverso peptide that competitively interferes with the interaction between FOXO4 and p53 in senescent cells, releasing p53 to the cytoplasm and inducing selective apoptosis of those cells.
In the defining Cell paper, FOXO4-DRI neutralised senescent cells in fast-aging XpdTTD/TTD mice and naturally aged mice, restoring fitness, fur density and renal function 1. It is one of the foundational compounds of senolytic research.
At a glance
- Selective senolytic mechanism (FOXO4–p53)
- Published in Cell (2017)
- 10 mg vials
Research use only. All products are sold strictly for laboratory research and development purposes. They are not intended for human or veterinary use, diagnosis, treatment, cure or prevention of any disease. Not for human consumption. Summaries above describe published findings in laboratory and clinical research models and do not constitute claims about this product.
- Form
- Lyophilized powder
- Purity
- HPLC-verified — Certificate of Analysis available on request
- Pack size
- Box of 10 vials
- Storage
- Lyophilized: −20 °C, protected from light (2–8 °C short-term). Reconstituted: 2–8 °C.
- Mol. weight
- ~4900 g/mol
Sequence, formula and CAS data are provided for identification. Batch-specific purity, mass-spec and HPLC data are on the Certificate of Analysis — ask for it with your order.
- Baar MP, Brandt RMC, Putavet DA, et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell. 2017;169(1):132-147.e16.
Citations retrieved from PubMed (NCBI). Links open the publisher record via DOI and the PubMed abstract.
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